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doi: 10.1172/JCI76012 83 GergelyPJrGrossmanCNilandBPuskasFNeupaneHAllamFet al

An increasing body of clinical evidence indicates that iron overload is a significant factor contributing to the death of bone marrow cells in patients with hematologic diseases [98, 99]

consider calcifediol when faster repletion or persistent SHPT is relevant), avoid mega-bolus dosing, and reserve active VDRAs for clear SHPT indications with careful calciumphosphatePTH monitoringnot as disease-modifying therapy in unselected CKD

Some studies also discovered that copper increased the expression of autophagy-related genes, such as LC3b/LC3a, p62, Atg3, Atg5 and BECN1 [68, 74]

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