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SIRT3 and PGC-1 can be mutually regulated, and both decreased in HFD-fed mice, this downregulation of SIRT3 caused mitochondrial proteins hyperacetylation and enhances fat storage and oxidative stress in the liver [181]

Future studies are needed to understand the role of coagulation perturbation in PSC and in CCA progression, to possibly provide the rationale for testing modulatory agents of blood coagulation/fibrinolytic system in PSC and CCA patients

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Zhu JK (2002) Salt and drought stress signal transduction in plants

Multiple furanoterpenoids, can be classified into three types of furanomonoterpenes, furanoditerpenes and furanotriterpenes (Yu et al., 2014), rutaevin (Zhang et al., 2020a), distributed in Meliaceae medicinal plants