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PASC that persist for more than 4 weeks after the acute infection are termed long COVID [12, 26, 31], with varying incidences between 10 and 70% of infected COVID-19 patients developing long COVID symptoms, depending on the study population examined, e.g., non-hospitalized, hospitalized or vaccinated patients, etc

When the attachment site is inter-chain cysteine thiol group, an antibody may have only one or few cysteine thiol groups through which a linker may be attached

These inflammatory proximal tubular cells can significantly downregulate GSH metabolic genes, making cells more prone to ferroptosis, resulting in repair failure after kidney injury, ultimately promoting kidney fibrosis and the progression of AKI to CKD (209)

Effects of naringenin on allodynia and hyperalgesia in rats with chronic constriction injury-induced neuropathic pain

Therefore, one possible explanation for AS-IV's suppression of HSC activation is its targeted effect on the upregulation of GSH content and Nrf2 activity