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Sirtuin 3 as a regulator of oxidative stress Sirtuin 3 is an NAD + -dependent deacetylase that plays a role in mitochondrial metabolic processes, including energy production, oxidative stress, the tricarboxylic acid cycle, and other processes (Bause et al

This upregulation of miR-449a inhibits the expression of its target gene ACSL4, thereby suppressing neuronal ferroptosis (139)

If therapy is unsuccessful, the brain loses as many neurons each hour as it does in approximately 3.6 years of average aging [16]

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