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Despite these breakthroughs, resistance to KRAS-targeted therapies remains a significant obstacle, and combination therapies may be a promising strategy to overcome this resistance

Strikingly, IFIT1 expression was induced by JFH1 wt about 150-fold, explaining the decreased replication at later time points, but not by JFH1 D1467G, suggesting that D1467G indeed also ablated RLR activation (Fig