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however, it can convert non-toxic particle into toxic ones due to enhanced bioavailability

doi: 10.1038/ki.2014.128 106 AlicicRZJohnsonEJTuttleKR

Selected adults may increase to 7.2 mg after at least four weeks at 2.4 mg when additional weight reduction is clinically indicated. The 0.25 mg dose is the starter rather than the maintenance target

Jastrzb R, Graczyk D, Siedlecki P