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Animals and ethic statement Thirty-eight 1012 week-SpragueDawley rats (male, 270320 g, Charles River Laboratories, MA) were used in accordance with the guidelines of the Johns Hopkins University for the Care and Use of the laboratory Animals (ACUCs approved protocol #RA17M296)

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The transcobalamin II-cobalamin complex enters the portal circulation, where it is delivered to the liver for storage and for secretion into the bile

S.et al (2005)

Its unique mechanism of action makes it an important compound for studies focused on inflammation, recovery, and vascular health