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For arthritis specifically, semaglutide has evidence from the STEP-9 knee osteoarthritis trial and studies on rheumatoid arthritis joint outcomes, while tirzepatide has shown roughly a 33% reduction in hsCRP and an 18% reduction in IL-6 (key inflammation markers) in meta-analyses

[DOI] [PMC free article] [PubMed] [Google Scholar] 239.Okyere J, Aboagye RG, Ahinkorah BO, et al

Considering the association between sleep deprivation and immune response to infections, vaccination studies allow to assess the impact of sleep and sleep loss on ongoing immune response and the clinical outcome