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Traditional drug development has often fallen short in effectively curing liver-related conditions, and these treatments frequently result in severe adverse reactions [225]

10.1016/j.phrs.2019.104489 Pharmacol Res

As discussed above, NO dysfunction is a hallmark of CMD and mismatched myocardial oxygen supply-demand in ischemic heart disease, HCM, and HFpEF, among other cardiac conditions (Van Heerebeek et al., 2006)