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Finally, the long-term effects are still unknown: indeed, it has been demonstrated that a prolonged AAV9-mediated SMN overexpression in mice induces dose-dependent, late-onset motor dysfunctions associated with neurodegeneration 9

This result was different from that of another meta-analysis that was published with L-carnitine supplementation in this scenario

Both caloric restriction and KD decrease inflammatory and pro-apoptotic activities through activation of PPAR (125, 126)

Prevention of hypercalciuria and stone-forming propensity during prolonged bedrest by alendronate