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Less threatening reaction to B1 include anxiety, pruritus, respiratory distress, nausea, abdominal pain

The biphasic dose-response The finding that 50 mg/mL outperformed 100 mg/mL mirrors what was observed in the laboratory copper peptides show optimal activity within a specific concentration window

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[6] [42] [43] For single doses of lipophilic, multi-compartment drugs, clinical duration after onset is often driven by the distribution () phase, because by the time distribution equilibrium is reached plasma levels are frequently below any minimal effective concentration, so the terminal phase has little bearing on observable effects