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Additional clinical trials are essential to confirm the efficacy of ferroptosis inhibitors in treating CVDs

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Gondin J, et al

W.RussoS

Initially, the IU/JAX/PITT group created mice that are double homozygous for APOE4 and Trem2 R47H (termed LOAD1) ( APOE4 is the greatest genetic risk factor for LOAD which is thought to increase the risk for AD through both gain and loss of function effects on multiple processes in the brain including amyloid clearance, synaptic plasticity, and cerebrovascular health ( TREM2 R47H is a rare coding mutation with a partial loss of function that alters the behavior of microglia ( via CRISPR/CAS9