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In gametes, DNMTs also establish a differential DNA methylation on ICR (Imprinting Control Regions) a phenomenon known as paternal or maternal imprinting depending on whether it takes place in male or female germ cells (Kaneda et al., 2004

Tissue reorganizes at a structural level

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This rodent model can be divided into two phases: (1) initial demyelination in the corpus callosum and other brain regions, such as the superior cerebellar peduncles and cerebral cortex (Vega-Riquer, 2019), which is accompanied by activation of the innate immune system, and (2) significant remyelination of exposed axons once cuprizone treatment is terminated (Gharagozloo, 2022)