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This functional diversity is often studied using the M1/M2 polarization model, which provides a valuable in vitro framework for distinguishing between pro-inflammatory and pro-resolving states

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In addition, there is a higher intensity of CD38 expression (measured by flow cytometry) in the more aggressive multi-hit variants, which allows further differentiation of the diseases and the use of CD38 as a biomarker for early diagnosis [14]

Post-treatment Lyme disease is a syndrome that could occur up to 6 months after treatment