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Additionally, there are certain classes of medications that hinder healing, including immunosuppressants, corticosteroids, non-steroidal anti-inflammatory drugs (NSAIDs), and anticoagulants

The rationale for combining these two agents is deeply rooted in the complementary biology described above

However, local circuit effects must be considered when deciphering pre- versus postsynaptic localization of opioid receptor actions, as postsynaptic hyperpolarization can reduce local circuit neurotransmitter release (Figures 2A,B)

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