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Conclusion: Linafexor (CS0159), a pulse FXR ligand with a short half-life, demonstrated significant efficacy in treating NASH by modulating the metabolic cycle of bile acids in accordance with circadian rhythms

(2025) 20:adb673

Clinical Applications: Supports Cardiovascular, Neurological, and Endocrine System Health*

Interestingly, mice fed a high-fat diet exhibited lower expression of ZIP7, consistent with the onset of insulin resistance in muscle (266) ( Figure 3B )