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High triglycerides (a type of body fat), blood sugar spikes, and increased risk of pancreatic disease Liver problems, shown by elevated liver enzymes in blood tests or, rarely, jaundice Digestive issues, including nausea or diarrhea, especially in those with inflammatory bowel disease Blood disorders, including low platelet or red blood cell counts Allergic reactions, often due to capsule preservatives Respiratory or vocal symptoms, especially in people with asthma Menstrual irregularities, including missed periods Accutane can remain in sperm for weeks after stopping intake