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J Reddy J, Z Liao Z, L Levy L, Q Nguyen Q, C Tang C, A Vaporciyan A, J Heymach J, JY Chang JY , RU Komaki RU, DR Gomez DR

Since drugs in this pipeline target and enhance autophagy, a cellular degradation pathway which is critical for the functioning of all cells and declines with age, they also represent exciting candidates for prevention of cognitive decline and other degenerative diseases of aging

Targeting STING with covalent small-molecule inhibitors

This study elucidates the previously unexplored role of alanine synthesis in activated HSCs for protecting against liver diseases via ammonia detoxification