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In the context of reperfusion therapy, recombinant tissue plasminogen activator is a key treatment for ischemic stroke, facilitating thrombolysis and improving neuronal and vascular recovery during cerebral ischemia and reperfusion injury

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Interestingly, down-regulation of immediate early genes, altered synaptic signaling, an anxiety-like behavior, and mild neuronal loss have been observed in these transgenic mice, suggesting that increased TMEM106B levels negatively impact brain health [199]

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