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It promotes insulin resistance by interfering with insulin signaling in peripheral tissues

556: Postmenopausal Estrogen Therapy: Route of Administration and Risk of Venous Thromboembolism

Ahhhh, what a shame, though I'd have too admit I did think that might be the case

We used a previously reported small-molecule peptide that competently inhibits -syn hyperphosphorylation at ser129 [13] and administered it to mice via the tail vein (Fig