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LINC01127, in collaboration with Mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4), activates the JNK pathway to enhance the communication with the NF-B pathway, culminating in the augmentation of the migratory capabilities and the self-renewal rate of glioma stem cells (GSCs) [151]

The overexpression of NAMPT cDNA in glioma or colorectal cells increased their tumorigenic properties, as well as their acquisition of the CSC phenotype and properties in culture