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Indole derivatives play a crucial role in the inflammatory response of colon tissue in UC and CD through the aryl hydrocarbon receptor (AhR) pathway [113]

cAMP response element modulator induces dual specificity protein phosphatase 4 to promote effector T cells in juvenile-onset

In this study, we demonstrate all the tenets of trained immunity modulation as a result of SIRT3 overexpression: (1) there is long-term functional reprogramming of HSCs by SIRT3 expression, as demonstrated by decreased HSC response to trained immunity programs, reduced inflammation and improved function of distant tissues (Figs