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For example, minoxidil may cause skin irritation such as itching and stinging, while finasteride may cause erectile dysfunction in men with long-term use [6,7]

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G-protein-independent signaling [edit] Although they are classically thought of working only together, GPCRs may signal through G-protein-independent mechanisms, and heterotrimeric G-proteins may play functional roles independent of GPCRs

The expression patterns shift toward healthier, more youthful states