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The trial randomised adults with obesity who have achieved 5% WL by the end of the 12-week lead-in period (mean WL at the lead-in period was 6.9%) to placebo or tirzepatide

It is proposed to work by binding GHRH receptors on pituitary somatotroph cells, prompting the pituitary to synthesize and release its own growth hormone in a pulsatile pattern, with the body's somatostatin feedback loop still intact so the effect is self-limiting rather than a constant hormone flood

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Those taking tirzepatide, managed an additional 5.5% WL from randomisation, compared to those taking placebo who experienced mean weight regain of 14% from randomisation [49]

doi: 10.1177/0883911503040432 [DOI] [Google Scholar] 32.Syam S, Abdelwahab SI, Al-Mamary MA, Mohan S