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CMS has no way to determine whether the ACO would have generated savings or losses during a performance year for which it was not reconciled

A large reduction of red blood cells means that essential oxygen is not getting to all the tissues and organs that need it

Mice received intraperitoneal injections of either thymosin beta-4 at 6 milligrams per kilogram or saline as a control

5 Once steady state is reached, the washout period for AJOVY is similar for monthly and quarterly dosing (~5-6 half-lives) 6 Washout period defined as time until plasma concentrations of AJOVY are below a clinically relevant concentration and thus considered eliminated