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Berberine reverses multidrug resistance in Candida albicans by hijacking the drug efflux pump Mdr1p

Dipasquale D, Basiric L, Morera P, Primi R, Trscher A, Bernabucci U

Although the propargylamine moiety might be responsible for the protection afforded by clorgyline and l -deprenyl, the lack of any protective effect of pargyline in our system and in some other neuronal models (see Mytilineou et al, 1997) would indicate it not to be a general property of all propargylamine derivatives

This mechanistic action directly addresses the bioenergetic inefficiency observed in ME/CFS and Long COVID, helping to restore baseline cellular energy levels and potentially raising the threshold for post-exertional malaise (PEM)

Mulder, D