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6I) revealed that YTHDF1 knockdown significantly down-regulated cytochrome C, while up-regulating Ferritin, TFAM, and GPX4, while SLC7A5 overexpression reversed the expression pattern of these proteins

Down-regulation of a hepatic transporter multidrug resistance-associated protein 2 is involved in alteration of pharmacokinetics of glycyrrhizin and its metabolites in a rat model of chronic liver injury

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Therefore, it is essential to thoroughly validate mouse findings in humanized models, like patient-derived iPSC 3D brain organoids, to ensure they are applicable to humans