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However, it is not ideal for everyone

Paul S, Chakraborty S, Anand U, et al

It is also almost always fused to the N-terminus of the protein, which may limit your ability to purify it depending on your proteins structural configuration

Polymorphisms in glutathione S-transferase (GST) and heme oxygenase-1 (HMOX1) genes, which are important for oxidative stress defense, modify these beneficial effects 39