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Current strategies in leveraging TYR as a therapeutic target mainly focus on synthesizing and applying small-molecule inhibitors to suppress TYR activity, which results in decreased melanin generation to alleviate skin diseases 13,14

Several mechanisms likely contribute to hydrogen water's ability to enhance SOD expression and activity: Activation of the Nrf2-Keap1 pathway, a master regulator of antioxidant response Modulation of cell signaling pathways that influence gene expression Reduction in oxidative stress that would otherwise impair SOD function Mild hormetic effects that stimulate adaptive cellular responses This ability to enhance SOD activity represents a significant advantage over direct SOD supplementation, as hydrogen water works with the body's natural systems to improve endogenous antioxidant capacity rather than simply providing exogenous antioxidants

Fulghesu, A

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Davies MJ