l carnitine in ckd Supplementation Chronic Hemodialysis Patients—A Literature Review NKF KDOQI Guidelines

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The combination of R(+)LA with HMB was the only treatment able to significantly reduce DEX-dependent redox imbalance, by reducing the concentration of O 2 and the level of carbonylated proteins, an oxidative modification due to the introduction of carbonyl groups into protein side chains leading to decreased functionality [69]

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Morphologically, it is marked by mitochondrial shrinkage, increased density of the double-layered membranes and the loss of mitochondrial crests