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Rather than inducing desensitization, a chronic morphine treatment could promote a compensatory increase in intracellular cAMP level (also named cAMP overshoot or ACase superactivation) (Avidor-Reiss et al., 2009)

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Developmental exposure to TCDD reduces fertility and negatively affects pregnancy outcomes across multiple generations

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Obesity causes renal mitochondrial dysfunction and energy imbalance and accelerates chronic kidney disease in mice