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2.1.1 Inhibitors of mitochondrial complex I Metformin, a CI inhibitor, effectively disrupts cellular and mitochondrial respiration by inhibiting complex I, which is closely associated with NADH-related respiration (Pollak, 2012)

The author is deeply grateful to his loving mother, Graciema Britto de Andrade, for her permanent, untiring, and enthusiastic support (in memoriam)

IN VITRO SCALING OF NEBULISED DOSES OF ETD001 FOR CLINICAL TRIALS IN PAEDIATRIC SUBJECTS WITH CYSTIC FIBROSIS Eddie J French 1, Samantha Heath3, Joanne Charlwood2, Paul Russell2 Kathy Woodward2 Niyati Prasad2 & Thomas Moody3 1TEKH Consulting Limited, Queen Street Deal CT13 6EY UK 2Enterprise Therapeutics Ltd., Sussex Innovation Centre, Falmer, Brighton, BN1 9SB, UK 3Intertek Melbourn, Saxon Way, Melbourn, Hertfordshire, SG8 6DN, United Kingdom Summary: Early clinical trials are usually undertaken solely in an adult population