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Cognitive function in obese individuals improves substantially with weight loss alone, but the direct central GLP-1R effects may contribute additional benefit beyond what weight reduction alone would predict

For example, lipid droplet accumulation in cancer cells has been shown to inactivate immune signaling molecules and foster a hospitable environment for cancer cell progression (144)

doi: 10.1007/s13760-016-0697-z 165

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Others are mechanically unstable and cause locking or catching that requires surgical intervention