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J Pharmacol Exp Ther 164 : 122134 Blokland A, Bothmer J, Honig W, Jolles J

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doi: 10.3390/ijms21155331 173 FanC.HuangY

Upon binding, ivermectin causes a prolonged phase of chloride ion influx, resulting in hyperpolarization, neuronal firing inhibition, paralysis, and ultimately, death of the parasite ( -aminobutyric acid (GABA)-gated chloride channel at higher concentrations, to further inhibit nervous system dysfunction in susceptible parasites (78)