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125127 When pyruvate kinase is deficient or dysfunctional, there is an increased reliance on alternative pathways for energy production leading to increased breakdown of ATP and subsequent accumulation of adenosine monophosphate

3.2.7 Lead (Pb) Lead is a well-known toxic element, and exposure to lead can come from a variety of sources such as food, water, paint, air, and occupational settings (Vig and Hu, 2000)

Nature 627, 149156

Typically, studies tend to be conducted In Vitro first, so within a lab or test tube environment, before moving on to In Vivo when it is deemed safe enough to do so

Shi S, Lei S, Tang C, Wang K, Xia Z (2019) Melatonin attenuates acute kidney ischemia/reperfusion injury in diabetic rats by activation of the SIRT1/Nrf2/HO-1 signaling pathway