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Other complications of traumatic brain injury include pulmonary edema and cardiac arrhythmia

In a separate rat study, the brain and brain mitochondria were shown to be enriched in CoQ 10 following a two-month supplementation regimen at a dose of 200 mg CoQ 10 /kg per day [188]

Search for specific biomarkers based on markers of necroptosis may be more precise and effective in LGG and GBM management, which may provide new clues for immunotherapy and prognosis

Key gaps include: No large-scale randomised controlled trials in humans the evidence basis for clinical use is extrapolated from animal data and small pilot studies No long-term safety data effects beyond 1216 weeks are not well characterised Variable results in human sleep trials some early human studies showed modest or inconsistent effects on sleep architecture compared to animal data, suggesting the translation may not be linear No FDA approval DSIP is not approved for any therapeutic use in the United States Stability concerns DSIP degrades relatively quickly in circulation

10.1101/2023.02.14.528517 39 ChenF.MaK.MadajewskiB.ZhuangL.ZhangL.RickertK.et al (2018)