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HIF-1 is upregulated in PASMCs of chronic cobalt chloride-induced PAH rats, which phosphorylates Drp1 by increasing Cyclin B/CDK1, subsequently leading to increased expression of the PDHK2 and PDHK4 genes, resulting in increased lactate production and promotion of glycolysis

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Moxibustion was paused when if patient felt stinging or when the treated skin was flush or very perceived as hot

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