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Proteins, lipids, and DNA of hepatocytes are among the cellular structures that are primarily affected by the oxidant and antioxidant imbalance within the cell, which participates in the course of inflammatory, metabolic, and proliferative liver diseases

Collectively, these findings indicate that, under defined pathological and catalytic conditions, GSH can be repurposed from an antioxidant safeguard into a redox driver that amplifies oxidative stress and promotes cell death in tumor and inflammatory contexts

Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, et al

Methods: We retrospectively identified patients with HCC who received 1 of 5 ICI regimens indicated for HCC, patients with various non-HCC cancers who received the same ICI drugs, and HCC patients who received sorafenib between 2010-2020

Inflammation and oxidative stress in multiple sclerosis: consequences for therapy development