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Combined methylmalonic aciduria and homocystinuria Late onset disease has better prognosis compared to early onset forms Methods: Case 1: 20yearold male with history of recurrent focal seizures since 5 years of age, acute encephalopathy at 6 years of age followed by poor scholastic performance and progressive spastic paraparesis wheelchair bound since past 2 years

10.1016/j.btre.2021.e00595 210 UsmanM.FarooqM.WakeelA.NawazA.CheemaS

Cellular metabolism Research indicates that lactylation of histones regulates glucose metabolism in various cell types, primarily by influencing glycolytic activity

We use this pipeline to further characterise a combination of two novel ECM peptide mimics (GPKG and LSVD) which act in vitro to enhance the transcription of ECM organisation and cell proliferation genes and in vivo to promote epithelial and dermal remodelling

Inhibitory interaction of flavonoids with organic cation transporter 2 and their structure-activity relationships for predicting nephroprotective effects