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Meanwhile, iMSC Exos could effectively increase the formation of autophagosomes and autolysosomes in mouse germ cell specific protein 1/spermatogenesis associated protein, enhance autophagy flux and reduce P62 protein accumulation, improve Cd-induced autophagy flux deficiency, promote spermatogonial proliferation and differentiation, protect mice from Cd-induced germ cell apoptosis, and cope with the decline in reproductive ability caused by Cd in environmental pollution (112)

This enhanced activity may be attributed to the plausible augmentation of the total phenolic content by CMSSF

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