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Class I FINs activate ferroptosis by depleting intracellular GSH by inhibiting system X c - [17, 95, 103, 104]

In most Gram-negative bacteria, the TS is backed up by a glutathione-glutaredoxin (GSH) system that is also able to scavenge reactive oxygen and nitrogen species in order to maintain redox homeostasis ( Helicobacter pylori proves to be an exception to the classification rule as a GSH-independent bacterium ( Mycobacterium tuberculosis , which does not fit within the Gram classification, is TrxR-dependent and GSH-independent ( Staphylococcus spp., Streptococcus spp., Enterococcus spp., or the exceptional GSH independent bacteria H

Non-enzymatic antioxidants include pigments, vitamin E, tocopherol, AsA, and GSH (Wingsle and Hallgren, 1993)

They are a dynamic equilibrium process catalyzed by an enzyme called glutathione reductase (GR)