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For decades, the prevailing view has been that homotypic K48-linked polyubiquitin chains represent the canonical degradation signal recognized by the proteasome

Signs of acute tennis elbow include pain that developed recently following increased activity, tenderness directly over the lateral epicondyle, pain that worsens with resisted wrist extension, and morning stiffness that improves with movement

In support of the NRF2 pathway being a potential target for the treatment of ALS, studies have shown that NRF2 overexpression in astrocytes provided neuroprotection against mutated SOD1-induced toxicity and increased the median survival of mutant SOD1 transgenic mice (Vargas et al., 2008

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