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TAAR1-stimulated RhoA Activation Mediates AMPH-stimulated Internalization of Both Catecholamine Transporters Using these primary culture models, we re-examined the mechanism of action of AMPH

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Consisting of dimeric transcription factors such as Jun and Fos, AP-1 binds to DNA motifs, such as TPA-responsive element (TRE) and cAMP-responsive element (CRE), initiating transcription of genes critical for cell survival and stress adaptation 73,74

For example, in the human hepatocytes used in [36], the cellular GSH concentration increased by 80% from day 1 to day 7

In particular, Trastuzumab emtansine (Kadcyla, T-DM1) that comprises an HER2-targeted antibody, a non-cleavable linker and a microtubule disrupting agent as the payload, and Trastuzumab deruxtecan (Enhertu, T-DXd), which is composed of a HER2-targeted antibody, a cleavable linker and a Topoisomerase I inhibitor as payload