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Research in aged primates demonstrates that Epithalon administration significantly increases nighttime melatonin levels in senescent monkeys while showing minimal effects in young animals, indicating specific targeting of age-related dysfunction

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10.1016/j.toxicon.2018.04.029 63 DuchG.SandersonJ

Both genetic deletion and chemical inhibition of TRF1 have been shown to block the growth of lung carcinoma, glioblastoma, and renal cell carcinoma in mice without affecting mouse survival or tissue function, making TRF1 a potential therapeutic target in cancer 1,2,3