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Lancet 1980- 15:1072-4 Sheppard K, Ryrie D

Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II

In research models with elevated NNMT activity, this methylation reaction has been reported to deplete cellular SAM pools and reduce NAD+ availability