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Table (3): ADME validation of the metabolites from Burkholderia stagnalis Selected bioactive metabolites obeyed Lipinskis rule of 5 without any violation suggesting their possibility of oral administration, The boiled egg plot evaluate the pharmacokinetic properties of the 24 bioactive metabolites, helping to predict their bioavailability and potential therapeutic applications (Figure 6)

Research indicates that IGF-1 inhibits inflammation and accelerates angiogenesis through Ras/PI3K/IKK/NF-B signaling pathways, creating an optimal environment for tissue repair