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Mechanistic investigations often pair 5-Amino-1MQ treatment with transcriptomic and proteomic analyses to map the downstream signaling changes that accompany NNMT inhibition, establishing a fuller picture of the enzyme's regulatory network

This process is manifested by upregulation of cytokines and chemokines and by the inflammatory cell infiltration of the pancreas (81)

We also used a virus-based approach to examine this neural connection between the small intestine and the brain, specifically by infusing a retrograde AAV2/Retro-hSyn-Cre virus into the small intestine and a Cre-dependent AAV-DIO-mCherry virus into the DMV of C57 mice (Fig

Proc Natl Acad Sci 93(3):10061011

Levodopa is a dopamine precursor used in Parkinson's disease therapy