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Our Western blot results displayed that basal LC3-II was slightly increased, although not significant, in APOE 3/4 + PSEN1 fibroblasts over controls (Figures 5F, G)

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Demonstrating the hormetic benefit of this response in a variety of brain cells, overexpression of PGC-1 protected against cell death induced by H 2 O 2 or paraquat treatment, and this occurred in conjunction with changes in gene expression similar to those observed with the 10T1/2 cells [76]

These findings suggest that lactylation resulting from elevated lactate levels during the I/R phase is associated with key cellular processes, including energy metabolism, neuronal injury, and repair