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N., Nicoli J

For the strong performance of ProTox-II (sensitivity, specificity and precision of 76, 95 and 75%, respectively) and superiority over other toxicity prediction tools, indicating their possible applicability for other compound classes 38

Prolonged therapy and higher doses of metformin correlate with decreased serum B12 levels, contributing to neuropathy, anemia, and cognitive impairment in diabetic patients

Malekizadeh, Y

[PubMed: 36806430] (42 year old woman presented 4 hours after an intentional overdose of 6000 mg of ALA and 7.5 gm of acetaminophen with refractory seizures, metabolic acidosis [pH 7.29, lactate 8.79 mmoL], with progressive multiple organ failure and cardiac arrhythmias resulting in death within 26 hours [CPK 848 rising to 14,447 U/L, ALT 15 to 53 U/L, AST 15 to 122 U/L, INR 1.1 to 3.0, creatinine 0.6 to 3.4])