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In the CNSs immune processes, gut microbiota can affect immune cell maturation and functionality, such as phagocytosis, antigen presentation, cytokine production, and inflammatory activation, ultimately affecting neurophysiological processes, including BBB stability and neurotransmitter synthesis (Liu et al., 2020)

To reduce this risk, some researchers: This approach may help maintain more consistent handling conditions during laboratory work

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In the first study, four peptides (EPAEAVGDWR, IPHESVDVIK, PDLSKHNNHM, and PFGNTHNNFK) were found to have the lowest docking energy with the DPP-IV enzyme, suggesting their potential as competitive inhibitors [115]

Repeating the experiment in these conditions resulted in an improvement in mice survival [108]